Review of COVID-19 results in SCD, SCT

New data from an extensive review of the literature found that although most studies reported mild to moderate disease progression related to COVID-19 in patients with sickle cell disease (SCD) or sickle cell trait (SCT), the literature suggests that SCD is associated with an increased risk of hospitalization and death from COVID-19, unless compared to controls with similar comorbidities and target organ damage.

Principal Investigator, Wouter Hoogenboom, PhD, Research Fellow, Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, explained that many risk factors for a poor COVID-19 outcome were the same between people with sickle cell disease. or trait and the general population.

“And on top of that,” he added, “people with sickle cell disease also experience sickle cell-related symptoms, like pain attacks and acute chest syndrome, which also add to their vulnerability.”

This study is not the first that investigators have conducted regarding the relationship between COVID-19 and sickle cell disease, according to Tim Duong, PhD, Professor, Vice Chairman of the Department of Radiology Research, Albert Einstein College of Medicine, Montefiore Medical Center.

Their previous study which looked at a cohort of Bronx patients with COVID-19 and sickle cell disease or trait, produced mixed conclusions.

“So what we found while we were doing our study is that the literature on the effects of COVID-19 on sickle cell disease and the trait is sparse and controversial,” Duong said, “with some articles reporting positive effects, or positive results or better results than the general population, some reported worse results than the general population.

With their latest study, the investigators decided to perform a critical appraisal of the literature in order to better understand and integrate the available data on the subject.

The rest of the interview will soon be published on To follow HCPLive® and the Rare Disease Report® on Twitter so you don’t miss Hoogenboom and Duong discuss the nuances of their findings.

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